Study of chiral recognition of model peptides and odorants: Carvone and camphor
نویسنده
چکیده
An atomistic calculation of the interaction between peptide motifs and enantiomeric odorant molecules (carvone and camphor) is performed. The peptide motifs are mimics of segments of the helical receptor structure. The model shows that the enantiomers of carvone have distinctly different interaction profile with all peptides considered, but the enantiomers of camphor do not exhibit any significant enantiodifference. This parallels the experimental fact that the enantiomers of carvone have different smells, while those of camphor cannot be discriminated by olfaction. This is expected to be a pilot study in further atomistic calculations to understand molecular recognition in olfaction process.
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